Acquired gene mutations

Acquired gene mutations

Most DNA mutations related to breast cancer occur in single breast cells during a
woman's life rather than having been inherited. These acquired mutations of oncogenes
and/or tumor suppressor genes may result from other factors, like radiation or cancercausing
chemicals. But so far, the causes of most acquired mutations that could lead to
breast cancer are still unknown. Most breast cancers have several acquired gene
mutations.
Tests to spot acquired gene changes may help doctors more accurately predict the outlook
for some women with breast cancer. For example, tests can identify women whose breast
cancer cells have too many copies of the HER2 oncogene. These cancers tend to be more
aggressive. At the same time, drugs have been developed that specifically target these
cancers.