Is it safe to use opioid drugs
with other medications?
Only under a physician’ssupervision can opioids be used
safely with other drugs. Typically,
they should not be used with other
substances that depress the CNS,
such as alcohol, antihistamines,
barbiturates, benzodiazepines,
or general anesthetics, because
these combinations increase the
risk of life-threatening respiratory
depression.
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